How do you administer sodium thiosulfate?
Sodium thiosulfate is recommended to be administered via slow IV injection over approximately 10 minutes for acute cyanide poisoning to help limit hypotension. Sodium thiosulfate causes a mild osmotic diuretic effect and patients may infrequently notice increased urinary frequency during treatment.
How do you administer sodium thiosulfate for Calciphylaxis?
Dialysis patients: 25 g intravenously (IV) diluted in 100 mL of sodium chloride 0.9% administered over 30 to 60 minutes 3 times per week during the last hour of or after the hemodialysis session. Therapy should continue until complete resolution of symptoms.
Does sodium thiosulfate need to be diluted?
Dilute each mL of the 25% Sodium Thiosulfate with 1 mL of sterile water for injection (1:1 dilution) for a 12.5% (125 mg/mL) solution for administration. (This has an approximately equivalent isotonicity to a 2.3% sodium chloride solution). MUST be administered within 4 hours of reconstitution.
What is sodium thiosulfate injection used for?
SODIUM THIOSULFATE (SOE dee um thi oh SUHL feyt) is used to treat cyanide poisoning. If a poisoning or overdose occurs, get emergency help. Do not treat a poisoning or overdose yourself. It is also a protective medicine used to prevent or lessen the kidney damage that can be caused by cisplatin chemotherapy.
Can I use sodium thiosulfate?
Sodium thiosulfate, also spelled sodium thiosulphate, is used as a medication to treat cyanide poisoning, pityriasis versicolor, and to decrease side effects from cisplatin. For cyanide poisoning it is often used after the medication sodium nitrite and typically only recommended for severe cases.
Can sodium thiosulfate be given during dialysis?
Administration of intravenous sodium thiosulphate (STS) has been purposed to treat CUA in dialysis patients. Due to the poor tolerability of STS, characterized by nausea, hypocalcaemia, metabolic acidosis and QT-interval prolongation, its intralesional administration has been reported.
Can sodium thiosulfate make you sick?
Side effects of sodium thiosulfate include: Low blood pressure (hypotension) (infusion rate-dependent) Nausea/vomiting.
What are the benefits of sodium thiosulfate?
Sodium thiosulfate (STS) is an industrial chemical which also has a long medical history. It was originally used as an intravenous medication for metal poisoning. It has since been approved for the treatment of certain rare medical conditions. These include cyanide poisoning, calciphylaxis, and cisplatin toxicity.
What do you use sodium thiosulfate for?
Sodium thiosulfate (Intravenous) Uses for sodium thiosulfate. Sodium thiosulfate may be used to lessen some of the side effects of cisplatin (a cancer medicine). Before using sodium thiosulfate. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Proper use of sodium thiosulfate. Sodium thiosulfate side effects.
What is the preparation of sodium thiosulfate?
The laboratory preparation of the sodium thiosulfate salt involves the heating of aqueous sodium sulfite solutions along with sulfur. The production of Na2S2O3can also be accomplished by the boiling of aqueous NaOH (sodium hydroxide) with sulfur. The reaction for the method described above is given by
What is the use of sodium thiosulphate in iodometry?
The term “iodometry” describes the type of titration that uses a standardised sodium thiosulfate solution as the titrant, one of the few stable reducing agents where oxidisation of air is concerned. Iodometry is used to determine the concentration of oxidising agents through an indirect process involving iodine as the intermediary.
Is sodium thiosulfate dialyzable?
The invention provides a source of sodium thiosulfate via the dialysate used to cleanse the bool of toxic and metabolic waste in the patients undergoing hemodialysis, peritoneal dialysis, or gastro-intestinal dialysis for treatment of end-stage or near end-stage chronic renal disease. In the method of the invention, dialysis solution components contain therapeutic amounts of sodium thiosulfate, which when fully reconstituted for use as a single solution, deliver 20-130 mg/dl of dialysate.