Which nanoparticle is useful in photothermal therapy?
It has been shown that colloidal gold exhibits localized plasmon surface resonance (LPSR), meaning that gold nanoparticles can absorb light at specific wavelengths, resulting in photoacoustic and photothermal properties, making them potentially useful for hyperthermic cancer treatments and medical imaging applications.
What are the nanoparticles used in PTT therapy?
Other nanoparticles have also been utilized as suitable photothermal absorbers in PTT. Copper sulfide (CuS) nanoparticles have been demonstrated as effective photothermal transducers in PTT [38], PTT-radiotherapy [39], and PTT-PDT [40]. CuS nanoparticles display minimal cytotoxic effects, similar to gold nanoparticles.
Is photothermal therapy effective?
Therefore, photothermal therapy is a reliable and powerful treatment modality for cancer treatment (Fig. 9.8). Moreover, it is noteworthy that hyperthermia may boost therapeutic efficacy of radiotherapy and chemotherapy (Kamping, 2006; Datta et al., 2015; Datta et al., 2016).
What is photothermal cancer therapy?
Photothermal therapy (PTT) is a cancer treatment that induces cancer cell death by heat generated in tumor tissue exposed to near-infrared (NIR) light1. NIR absorbents are used for facilitating efficient heat production2.
What is the end outcome of photothermal effects?
Photothermal effect is a phenomenon associated with electromagnetic radiation. It is produced by the photoexcitation of material, resulting in the production of thermal energy (heat).
What is the difference between photothermal therapy and photodynamic therapy?
In PTT, a photothermal (PT) agent is employed for the selective local heating for healing abnormal cells or tissues; whereas, in PDT, the treatment occurs through a series of photochemical reactions triggered by photoactivated molecules or materials called photosensitizer (PS) drugs.
What are photothermal properties?
Photothermal therapy (PTT) is a minimally invasive technique where incident light is absorbed by nanoparticles and converted its energy to local heat within tumor tissue and it selectivity kills cancer cells with the induction apoptosis in them or directly through a rapid necrosis as the local temperature reaches to …
What is photothermal imaging?
Photothermal optical microscopy / “photothermal single particle microscopy” is a technique that is based on detection of non-fluorescent labels. The high sensitivity and selectivity of photothermal microscopy allows even the detection of single molecules by their absorption.
What is a photothermal material?
Photothermal materials can efficiently absorb and convert light energy into heat. The produced heat could be served in various applications, including phototherapy, photoimaging, and clean water production.
How are nanoparticles used in photothermal therapies?
The current status of the use of nanoparticles for photothermal treatments is reviewed in detail. The different families of heating nanoparticles are described paying special attention to the physical mechanisms at the root of the light-to-heat conversion processes. The heating efficiencies and spectral working ranges are listed and compared.
How is upconversion used to treat brain tumors?
In this regard, a functionalized upconversion nanoparticle (UCNP)-based delivery system which can target brain tumor and convert deep tissue-penetrating near-infrared (NIR) light into visible light for precise phototherapies on brain tumor was developed in this work.
How is the UCNP-based phototherapy delivery system acquired?
Methods: The UCNP-based phototherapy delivery system was acquired by assembly of oleic acid-coated UCNPs with angiopep-2/cholesterol-conjugated poly (ethylene glycol) and the hydrophobic photosensitizers. The hybrid nanoparticles (ANG-IMNPs) were characterized by DLS, TEM, UV/vis and fluorescence spectrophotometer.
How are Ang-imnps used in the treatment of brain cancer?
Conclusion: In vitro and in vivo data strongly indicate that the ANG-IMNPs were capable of selectively delivering dual photosensitizers to brain astrocytoma tumors for effective PDT/PTT in conjugation with a substantially improved median survival.