What causes hypercholesterolemia?
Familial hypercholesterolemia (FH) can be caused by inherited changes (mutations) in the LDLR, APOB, and PCSK9 genes, which affect how your body regulates and removes cholesterol from your blood. About 60-80% of people with FH have a mutation found in one of these three genes.
What is hypercholesterolemia?
Hypercholesterolemia can be defined as the presence of high plasma cholesterol levels, with normal plasma triglycerides, as a consequence of the rise of cholesterol and apolipoprotein B (apoB)-rich lipoproteins, called low-density lipoprotein (LDL).
What organelle causes hypercholesterolemia?
Familial hypercholesterolemia results from mutation of the LDLR (low-density lipoprotein receptor) gene. There are numerous different mutations in LDLR that can give rise to disease, including some that result in receptor dysfunction and others that result in decreased receptor production by cells.
What is the best treatment for hypercholesterolemia?
Statins. Statins are usually the first hypercholesterolemia treatment used. Statins help reduce LDL levels by blocking a specific enzyme that’s necessary to produce cholesterol. Along with lowering LDL cholesterol, statins help prevent hardening of the arteries, which reduces the chances of a heart attack or stroke.
What are two diseases associated with hypercholesterolemia?
Diseases that are tied to high cholesterol include coronary heart disease, stroke, peripheral arterial disease, type 2 diabetes and high blood pressure.
What should I eat if I have hypercholesterolemia?
Foods to include
- fatty fish, such as salmon, trout, albacore tuna, and sardines.
- nuts, seeds, and legumes.
- the skins of fruit.
- nontropical natural vegetable oils, such as olive oil, avocado oil, canola oil, and safflower oil.
What is prescribed for hypercholesterolemia?
Statins are usually the first hypercholesterolemia treatment used. Statins help reduce LDL levels by blocking a specific enzyme that’s necessary to produce cholesterol. Along with lowering LDL cholesterol, statins help prevent hardening of the arteries, which reduces the chances of a heart attack or stroke.
How is hypercholesterolemia diagnosed?
Clinical Diagnosis FH is usually diagnosed clinically with a lipid test that measures the amount of LDL cholesterol (LDL-C) in the blood, a physical exam, and a family history. Healthcare providers typically use well-established criteria, to determine how likely it is that someone has FH.
What you shouldn’t eat with high cholesterol?
To help improve your cholesterol numbers, you should not eat full-fat cheese or yogurt, or drink whole milk. Other high-fat dairy foods you should avoid include ice cream, cream cheese, heavy cream, half and half, sour cream and butter.
How can hypercholesterolemia be prevented?
Familial Hypercholesterolemia is a genetic disease; the only way to prevent it is to get a genetic counseling prior to conception. In an individual who already has the disease, the key to longer life is in controlling the cholesterol levels.
What is the best natural remedy for high cholesterol?
Allium Sativum is the natural medicine for high cholesterol levels. As this remedy is made from garlic, it is considered as the best natural medicine for cholesterol control as this helps in eliminating the excess cholesterol from the body by raising the vitality of the person.
What causes sudden increase in cholesterol?
Here are the cause of the rise of cholesterol: 1. Weight: Excess weight not only interfere with performance, but also raises triglycerides and lowers HDL or commonly known as good cholesterol. 2. Rarely exercise: although it seems trivial, less mobile such as exercise may increase LDL (bad cholesterol) and lowers good cholesterol.