What does dengue NS1 positive mean?
A positive NS1 test result confirms dengue virus infection without providing serotype information. A negative NS1 test result does not rule out infection. People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure.
How accurate is dengue rapid test?
The accuracy of the NS1 antigen rapid test is considered high with sensitivity 55%-82% and specificity 97%-100%. Since the NS1 rapid test aims to detect dengue NS1 antigen, it should be performed within 5 days of onset of fever.
Is there a rapid test for dengue?
Rapid diagnostic tests (RDT) for past DENV infection would offer a convenient method for pre-vaccination screening at point-of-care. A systematic review was conducted to evaluate the performance of current dengue RDTs for determining dengue serostatus, using IgG antibodies against DENV as a marker of past infection.
What is difference between dengue NS1 and IgM?
NS1 antigen is generally found during Day 1 and up to Day 9 after onset of fever. The detection of anti-NS1 is inhibited if anti-NS1 antibodies produced. Whereas IgM become detectable by Day 3 to Day 5 after onset of illness in primary dengue and by Day 1 to Day 2 after onset of illness in secondary infections.
How do you treat dengue NS1 positive?
Most cases of dengue can be treated at home if detected early. The NS1 antigen test is the most effective for early diagnosis of dengue infection. The main focus of treatment is to ensure that the patient gets adequate hydration. Acetaminophen (paracetamol) is used to manage the fever.
How long is NS1 positive?
NS1 Testing Positive test for DENV may mean that NS1 antigen is typically detectable within 1 to 2 days following infection and up to 9 days following symptom onset. NS1 antigen may also be detectable during secondary dengue virus infection, but for a shorter duration of time (1-4 days following symptom onset).
What happens if dengue test is positive?
A positive result means you probably have been infected with the dengue virus. A negative result can mean you aren’t infected or you were tested too soon for the virus to show up in testing.
How can I check my blood for dengue?
Two primary types of testing are available: Molecular testing (polymerase chain reaction, PCR)—this type of test detects the genetic material of the dengue virus in blood within the first week after symptoms appear (fever) and can be used to determine which of the 4 serotypes is causing the infection.
When should blood test be done for dengue?
Dengue NS1 Antigen This is a blood test to detect the dengue virus early in the course of an infection. When to get the test done: It should be done within the first five days of the appearance of symptoms because after five-seven days, the chances of false positive and negative results are high.
What happens if dengue IgM is positive?
Positive IgM and IgG tests for dengue antibodies detected in an initial blood sample mean that it is likely that the person became infected with dengue virus within recent weeks. IgM antibody tests can be positive if a person has been infected with a similar virus, such as chikungunya (called cross-reaction).
Is dengue NS1 curable?
There is no dengue cure available. The disease is usually self-limiting and goes away after two weeks in a typical infection. Some people, however, may become critical and have severe internal bleeding or dengue haemorrhagic fever.
How long does dengue NS1 stay positive?
The presence of dengue NS1 antigen is consistent with acute-phase infection with dengue virus. Positive test for DENV may mean that NS1 antigen is typically detectable within 1 to 2 days following infection and up to 9 days following symptom onset.
When to do NS1 test for dengue virus?
The link between the NS1 protein and the dengue virus has resulted in the formation of a new diagnostic tool for prompt and early detection of dengue. The test can be done within 24 hours and up to 7 days from the onset of the infection.
Are there any rapid diagnostic tests for dengue?
Non-structural glycoprotein-1 (NS1) has proven to be a useful biomarker for early diagnosis of dengue. A number of rapid diagnostic tests (RDTs) and enzyme-linked immunosorbent assays (ELISAs) targeting NS1 antigen (Ag) are now commercially available.
When did the NS1 antigen test come out?
A-Crystal-Structure-of-the-Dengue-Virus (which causes Dengue fever. NS1 antigen test (nonstructural protein 1), is a test for dengue, introduced in 2006.
What does DENV by NS1 antigen stand for?
DENV by NS1 antigen is laboratory confirmation of dengue in people also assessing clinical aspects (as well as, taking into account where the individual may have traveled recently).