What is AZA treatment?

Azacitidine and its deoxy derivative, decitabine (also known as 5-aza-2′-deoxycytidine), are used in the treatment of myelodysplastic syndrome. Both drugs were first synthesized in Czechoslovakia as potential chemotherapeutic agents for cancer.

What does 5 Aza do?

5-AZA-CdR is an effective epigenetic drug for the treatment of hematologic malignancies. The clinical efficacy of 5-AZA-CdR is due to its demethylating epigenetic action, which reactivates tumor suppressor genes silenced by DNA methylation.

Is azacitidine a chemotherapy?

Azacitidine is a chemotherapy drug. It is believed to work by helping your bone marrow grow normal blood cells so you will need fewer blood transfusions.

Who manufactures dacogen?

Beerse, Belgium (28 September 2012) – Janssen-Cilag International NV (Janssen) announced today that the European Commission has approved the marketing authorisation for DACOGEN® (decitabine) for the treatment of adult patients (age 65 years and above) with newly diagnosed de novo or secondary acute myeloid leukaemia ( …

Can azacitidine be given at home?

A nurse or other trained health professional will give you this medicine. You may also be taught how to give your medicine at home. This medicine is given as a shot under your skin or into a vein. This medicine is given once a day, for 7 days (1 treatment cycle).

How long can you take azacitidine?

We strongly recommend that patients be treated with azacitidine for a minimum of 6 months, and that in patients who achieve a documented response or stable disease (sd), treatment be continued until disease progression or unacceptable toxicity occurs.

What kind of chemical is 5 Aza?

Azacitidine is a cytosine analogue and antineoplastic agent used in the therapy of myelodysplastic syndromes….2Biologic Description.

IUPAC Condensed z5Cyt-Ribf
IUPAC 5-aza-cytidine

What are the side effects of azacitidine?

Azacitidine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea.
  • vomiting.
  • diarrhea.
  • constipation.
  • sores on the mouth or tongue.
  • hemorrhoids.
  • stomach pain or tenderness.
  • heartburn.

What are the side effects of decitabine?

What are some other side effects of this drug?

  • Hair loss.
  • Constipation, diarrhea, stomach pain, upset stomach, throwing up, or feeling less hungry.
  • Heartburn.
  • Feeling dizzy, tired, or weak.
  • Mouth irritation or mouth sores.
  • Trouble sleeping.
  • Headache.
  • Itching.

What kind of drug is Dacogen?

What Is Dacogen? Dacogen (decitabine) for Injection is a cancer (antineoplastic) medication used to treat myelodysplastic syndromes (certain types of blood or bone marrow cancer). Dacogen is available in generic form.

Why are alternative nucleoside used instead of RNA?

Due to the low stability of RNA, which is prone to hydrolysis, several more stable alternative nucleoside/nucleotide analogues that correctly bind to RNA are used. This is achieved by using a different backbone sugar.

How does azacitidine work as an antineoplastic agent?

It is thought to have antineoplastic activity via two mechanisms – at low doses, by inhibiting of DNA methyltransferase, causing hypomethylation of DNA, and at high doses, by its direct cytotoxicity to abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA, resulting in cell death.

What does Aza stand for in saving animals from extinction?

AZA’s Saving Animals From Extinction (SAFE) program prioritizes collaboration between zoos and aquariums to support highly vulnerable species. SAFE builds on existing recovery plans to implement strategic conservation and public engagement activities.

How are nucleosides and sugars related to each other?

While a nucleoside is a nucleobase linked to a sugar, a nucleotide is composed of a nucleoside and one or more phosphate groups. Thus, nucleosides can be phosphorylated by specific kinases in the cell on the sugar’s primary alcohol group (-CH2-OH) to produce nucleotides. Nucleotides are the molecular building-blocks of DNA and RNA.