What is the role of interleukin 8?
Interleukin-8 (IL-8) is a chemoattractant cytokine produced by a variety of tissue and blood cells. Unlike many other cytokines, it has a distinct target specificity for the neutrophil, with only weak effects on other blood cells. Interleukin-8 attracts and activates neutrophils in inflammatory regions.
Is IL-8 proinflammatory?
Interleukin 8 (IL-8) is a proinflammatory cytokine with proangiogenic, proliferative, and promotility activities. It is produced by multiple cell types and has been associated with tumor progression in several types of cancer.
Is IL-8 a chemokine?
CXCL8 (interleukin-8) is a member of the chemokine family that acts on CXCR1 and CXCR2 receptors. CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, and CXCL7 are also ELR+ chemokine members that bind to these receptors, especially CXCR2.
Which cytokines are pro-inflammatory?
The key pro-inflammatory cytokines are IL-1, IL-6, and TNF-α. These cytokines signal via type I cytokine receptors (CCR1) that are structurally divergent from other cytokine receptor types. They are crucial for coordinating cell mediated immune response and play a critical role in modulating the immune system.
What other names does interleukin-8 have?
Interleukin 8
| CXCL8 | |
|---|---|
| Aliases | CXCL8, chemokine (C-X-C motif) ligand 8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, IL8, C-X-C motif chemokine ligand 8, Interleukin-8, SCYB8 |
| External IDs | OMIM: 146930 HomoloGene: 47937 GeneCards: CXCL8 |
| showGene location (Human) | |
| showRNA expression pattern |
Do mice have IL-8?
IL-8 has been proposed to contribute to chronic inflammation and cancer. However, mice do not have the IL-8 gene, so human cancer cell lines and xenograft studies have been used to study the role of IL-8 in colon and gastric carcinogenesis.
Do monocytes produce IL-8?
Monocytes were more prominent producers of IL-8 mRNA than endothelial cells; baseline levels and induced levels were both higher for monocytes than for the other cell types. This is in agreement with monocytes being a specialized cell for the secretion of chemokines.
Are pro-inflammatory cytokines good or bad?
Cytokines may be “good” when stimulating the immune system to fight a foreign pathogen or attack tumors. Other “good” cytokine effects include reduction of an immune response, for example interferon β reduction of neuron inflammation in patients with multiple sclerosis.
Where does interleukin-8 come from in the body?
Interleukin-8 (IL-8) is a cytokine produced by many normal cells including monocytes, neutrophils, fibroblasts, and endothelial cells, as well as by several types of tumor cells, which served as a chemotactic factor for neutrophils and lymphocytes.36
Which is more potent Interleukin 8 or IL-8?
Interleukin 8 is synthesized as a precursor (99 amino acids) and processed to a mature secreted form (72 amino acids). In addition to a truncated form (69 amino acids) which is as potent as the mature IL-8, intermediately processed forms (79 and 77 amino acids) with weaker activities have been purified from culture supernatants.
What is the role of interleukin 8 in the inflammatory response?
Interleukin-8 (IL-8) is one of the major mediators of the inflammatory response. It is secreted by several cell types and functions as a chemoattractant and as a potent angiogenic factor.
What are the effects of interleukin 8 in mice?
When implanted into the peritoneum of immunocompromised mice, the high-expressing CXCL8 tumors were associated with a significant increase in mortality (all animals died within 51 days), and the expression of CXCL8 was associated with increased tumor vascularity.