How are proteins trafficked between the ER and the Golgi?
Correctly folded and assembled proteins in the ER are packaged into COPII-coated transport vesicles that pinch off from the ER membrane. Shortly thereafter the coat is shed and the vesicles fuse with one another to form vesicular tubular clusters, which move on microtubule tracks to the Golgi apparatus.
Where does protein trafficking occur in the cell?
The Golgi apparatus is involved in the sorting and trafficking of proteins produced within a cell. Proteins translated within the rough endoplasmic reticulum are transferred to the Golgi. From there they are modified and packaged into vesicles for distribution.
What transports proteins between the ER and the Golgi apparatus?
-vesicles transport proteins from the ER to the Golgi apparatus, between the various cisternae, and between the Golgi apparatus and the plasma membrane or other organelles.
What is protein trafficking explain with an example?
Protein trafficking is the transport of proteins to their correct subcellular compartments or to the extracellular space (“secretory pathway”). Endo- and exocytosis describe vesicle budding and fusion at the plasma membrane and are by most authors not included in the term protein trafficking.
What transports proteins in a cell?
The Golgi apparatus transports and modifies proteins in eukaryotic cells. The Golgi apparatus is the central organelle mediating protein and lipid transport within the eukaryotic cell.
What are the different routes of protein trafficking in a cell?
Vesicles transport proteins and lipids between these compartments via two major pathways: the outwards, exocytic pathway, carries material synthesized in the cytoplasm to the cell milieu, and the inwards, endocytic pathway, internalizes material from the environment to the inside of the cell.
How does the Golgi apparatus modify proteins?
The Golgi enzymes catalyze the addition or removal of sugars from cargo proteins (glycosylation), the addition of sulfate groups (sulfation), and the addition of phosphate groups (phosphorylation). Cargo proteins are modified by enzymes (called resident enzymes) located within each cisterna.
What is responsible for protein trafficking?
The Golgi apparatus
What happens in protein trafficking?
Protein trafficking is the transport of proteins to their correct subcellular compartments or to the extracellular space (“secretory pathway”). Protein quality control comprize all cellular mechanisms, monitoring protein folding and detecting aberrant forms.