How do you perform a sural nerve biopsy?

An incision is made, and the lesser saphenous vein is identified. The vein is then retracted superficially to expose the sural nerve. For a complete nerve biopsy, untied sutures are placed into both ends of the nerve, and the nerve is transected above these sutures.

Why do they do a sural nerve biopsy?

It is clear that sural nerve biopsy has an important place in the diagnosis of peripheral nerve disease and, in the case of vasculitic neuropathy confined to peripheral nerves, it is the only certain way of making the diagnosis of the treatable condition.

How do you test for CIDP?

The initial diagnosis of CIDP is based on signs and symptoms, but the diagnosis can be confirmed by evidence of peripheral nerve demyelination. This may be identified by either electrodiagnostic testing or by nerve biopsy. Electrodiagnostic testing is recommended for all patients with suspected CIDP.

What mimics CIDP?

Motor CIDP mimics include multifocal motor neuropathy and motor neuron disorder, while sensory CIDP can be confused with a host of neuropathic and non-neuropathic conditions that have a disturbance of skin sensation.

Where is the sural nerve?

The sural nerve is a cutaneous nerve, providing only sensation to the posterolateral aspect of the distal third of the leg and the lateral aspect of the foot, heel, and ankle.

Does sural nerve biopsy hurt?

The biopsy site may be tender or sore for two to three days after a nerve biopsy. Take a pain reliever for soreness as recommended by your physician. Aspirin or certain other pain medications may increase the chance of bleeding. Be sure to take only recommended medications.

Can CIDP go into remission?

Our five year follow up study showed that the long term prognosis of Japanese CIDP patients was generally favourable; 87% of the 38 patients were able to walk five years later, and 26% experienced complete remission lasting for more than two years without treatment.

How do you heal the sural nerve?


  1. Desensitization. Direct massage over the irritated nerve is designed to both desensitize the nerve and break up any scar tissue around the nerve.
  2. Medication. Medications like Gabapentin (Neurontin) or Pregabalin (Lyrica) may help to stabilize the irritated nerve.
  3. Corticosteroid injection.
  4. Comfort shoe wear.

What does sural nerve come off of?

The sural nerve has its origins within the sciatic nerve, coming from terminal branches of the tibial and common fibular nerves.

How long does it take sural nerve to heal?

Among the three nerve-injury groups, sural nerve recovery was slowest, with the presence of painful neuromas in its innervation zone. However, sensation in the above cutaneous nerve injury region gradually recovered to normal by 6 months to 1 year after surgery.

Is there additional diagnostic value of sural nerve biopsy in the diagnosis of CIDP?

CONCLUSIONAny additional diagnostic value of sural nerve biopsy in the diagnosis of CIDP could not be shown. Sural nerve biopsy is considered to be a valuable method for establishing the cause of peripheral neuropathies in specific circumstances, if it is evaluated by a neuropathologist experienced in modern techniques.

Can A sural nerve biopsy be used for peripheral neuropathy?

It is indicated in a few patients with peripheral neuropathy and should be done only after careful clinical, laboratory, and neurophysiological evaluation.Whether suspected chronic inflammatory demyelinating polyneuropathy (CIDP) is an indication for sural nerve biopsy studies remains inconclusive from reports in the literature.

Which is the most invasive sural nerve biopsy?

Sural nerve biopsy is the most invasive procedure of all these procedures and should be considered after the results of the other tests are known. However, little is known about the diagnostic properties of sural nerve biopsy in CIDP.

What are the neuropathologic features of CIDP [ 2 ]?

(See ‘Nodal and paranodal antibodies’ below.) Neuropathologic findings — The characteristic pathologic features of CIDP include segmental demyelination and remyelination of peripheral nerves, resulting in onion bulb formation [ 2 ].