What is the differential count of lymphocytes and monocytes?

Reference ranges for differential white blood cell counts are as follows : Neutrophils – 2500-8000 per mm3 (55-70%) Lymphocytes – 1000-4000 per mm3 (20–40%) Monocytes – 100-700 per mm3 (2–8%)

What could a high lymphocyte differential indicate?

High: A high lymphocyte level can indicate an acute viral infection, such as chicken pox, herpes, or hepatitis. Or, a lymphocyte count may be high because of a bacterial infection, such as tuberculosis or pertussis, or a condition such as lymphocytic leukemia or lymphoma.

Why would monocytes and lymphocytes be high?

Monocytes: High levels of monocytes may indicate the presence of chronic infection, an autoimmune or blood disorder, cancer, or other medical conditions. Lymphocytes: If there is an elevation in the level of lymphocytes, the condition is known as lymphocytic leukocytosis.

What could a high monocyte differential indicate?

A high monocyte count — also called monocytosis — is often associated with chronic or sub-acute infections. It can also be linked with some types of cancer, especially leukemia. A high monocyte count can occur when you are recovering from an acute infection.

What are the symptoms of high monocytes?

Having too many monocytes also causes many of the symptoms of CMML. These monocytes can settle in the spleen or liver, enlarging these organs. An enlarged spleen (called splenomegaly) can cause pain in the upper left part of the belly (abdomen). It can also cause people to notice they feel full too fast when they eat.

How to tell if a patient has malignant leukocytosis?

Leukocytosis, or elevated WBC count, is a commonly encountered laboratory finding. Distinguishing malignant from benign leukocytosis is a critical step in the care of a patient, which initiates a vastly different decision tree. Confirmation of the complete blood cell count and the WBC differential is the first step.

When do you need a manual leukocyte differential?

Whereas in many patients, a slide review may be adequate to confirm automated cell counts, in other cases (eg, abnormal cells, inaccurate automated leukocyte differential, or spurious leukocytosis), a manual leukocyte differential is necessary. Typically, 100 leukocytes are counted using microscopy.

What are the symptoms of large granular lymphocytic leukemia?

The following signs and symptoms may be present: Changes in blood cell counts. Decline in the production of red blood cells (red cell aplasia) Below-normal concentration of neutrophils, a type of white cell (chronic neutropenia) Decrease in the number of red cells (anemia) occurs in about half of patients.

Can a lymphoid biopsy show infectious mononucleosis?

The diagnosis of infectious mononucleosis (acute Epstein-Barr virus (EBV) infection) is usually made on the basis of clinical and laboratory findings. However, an atypical clinical presentation occasionally results in a lymph node or tonsillar biopsy. The morphological features of EBV-infected lymphoid tissue can easily mimic lymphoma.