What is CDK4 gene?

CDK4 (Cyclin Dependent Kinase 4) is a Protein Coding gene. Diseases associated with CDK4 include Melanoma, Cutaneous Malignant 3 and Hereditary Melanoma. Among its related pathways are Cell cycle Cell cycle (generic schema) and DNA Damage.

Is CDK4 a tumor suppressor gene?

In summary, our study focused on the mechanism of miR-486-5p as a tumor suppressor in NSCLC, and our findings revealed that it functioned, in part, through targeting CDK4, an important component of the CDK4/6 signaling pathway.

What is CDK4 function?

Authors uncovered the role of cyclin-dependent kinase 4 (CDK4), a clinically validated kinase important for cell-cycle progression, in regulating cap-dependent translation via phosphorylation of the tumor suppressor 4E-BP1. High CDK4 expression is associated with tumor growth and metastasis in osteosarcoma.

Which chromosome is CDK4 on?

Genomic organization of the CDK4 gene on chromosome 12. CDK4 is a relatively compact gene that spans 4.16 kb of genomic DNA on the long arm of chromosome 12, in the telomere-to-centromere orientation.

What is the function of cyclin E?

Cyclin E is the limiting factor for G1 phase progression and S phase entry. The cyclin E gene is a target of E2Fs, and the protein associates with Cdk2 and activates its kinase activity shortly before entry of cells into the S phase.

What does CDK4 do?

CDK4 and CDK6 are cyclin-dependent kinases that control the transition between the G1 and S phases of the cell cycle. The S phase is the period during which the cell synthesizes new DNA and prepares itself to divide during the process of mitosis.

What type of gene is CDKN2A?

CDKN2A is one of the most studied tumor suppressor genes. It encodes the p16-INK4a protein that plays a critical role in the cell cycle progression, differentiation, senescence, and apoptosis. Mutations in CDKN2A or dysregulation of its functional activity are frequently associated with various types of human cancer.

Where is CDK4 located?

CDK4 is a member of the cyclin-dependent kinase family….Cyclin-dependent kinase 4.

Location (UCSC) Chr 12: 57.75 – 57.76 Mb Chr 10: 127.06 – 127.07 Mb
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How many cyclin e genes are there?

Cyclin E

cyclin E1
Alt. symbols CCNE
NCBI gene 898
HGNC 1589

When is cyclin E the highest?

Cyclin E-Cdk2 activity is highest in G1–S cells and lowest in quiescent cells (Dulic et al., 1992; Koff et al., 1992; Ekholm et al., 2001).

Where is the CDKN2A gene?

The name CDKN2A stands for “Cyclin-Dependent Kinase Inhibitor 2A.” The gene provides instructions for making several tumor suppressor proteins. The CDKN2A gene is located on chromosome 9.

What are some examples of genetic mutations?

Examples of gene mutations include Marfan syndrome, cystic fibrosis and sickle cell disease. Chromosome mutation occurs when there are changes in the number or structure of the chromosomes. The mutation in relation to numbers typically occurs by the time the zygote is forming or developing inside the womb.

Can mutations be genetically inherited?

Gene mutations occur in two ways: they can be inherited from a parent or acquired during a person’s lifetime. Mutations that are passed from parent to child are called hereditary mutations or germline mutations (because they are present in the egg and sperm cells, which are also called germ cells).

What is a genetic mutation?

Genetic mutations. Definition. noun. Changes in the nucleotide sequence of thegenetic material (i.e. DNA, or RNA, in the case of viruses), which are usually caused by copying errors during replication that further lead to base substitution, insertion, or deletion of one or more base pairs.