Why is antiplatelet used in myocardial infarction?

Antiplatelet drugs play a crucial role in the treatment of patients with myocardial infarction, particularly in association with percutaneous coronary intervention. Their main advantage is the reduction of adverse ischemic incidents and the major disadvantage is the increase in the frequency of hemorrhages.

Do you give clopidogrel in STEMI?

Oral clopidogrel (Plavix) at a dosage of 75 mg daily should be added to aspirin therapy in patients with STEMI, whether or not they undergo reperfusion therapy. Oral beta blocker therapy should be initiated within 24 hours of STEMI in patients with no contraindications.

Why is clopidogrel indicated for STEMI?

Recent large randomized trials have demonstrated that the addition of clopidogrel to aspirin reduces the risk of major ischemic events by up to a further one-third in patients with STEMI treated with fibrinolytic therapy and undergoing percutaneous coronary intervention, with no significant increase in bleeding.

When do you give heparin in stemi?

The AHA guidelines say we should be giving heparin to patients undergoing revascularization or receiving fibrinolytics, however all their recommendations are evidence level C, which translates to “only consensus opinion of experts, case studies, or standard-of-care”.

What medications do you give for a STEMI?

Initial medical therapy during STEMI consists of oxygen administration, antiplatelet therapy (aspirin, thienopyridines and glycoprotein IIb/IIIa inhibitors), anticoagulation (heparin or bivalirudin), anginal pain relief with nitrates and morphine, and beta-blockade.

How do you avoid STEMI?

STEMI = ST-segment elevation. PCI = percutaneous coronary intervention. Most patients will need dual antiplatelet therapy (DAPT) for 12 months, an angiotensin-converting enzyme inhibitor (ACEI), a beta-blocker, and a statin, all of which have been shown to reduce the risk of coronary death.

What drugs do you give for a STEMI?

Do you give heparin for STEMI?

Heparin (i.e. “unfractionated”) bolus dose of 5000 units should be given in cases of patients who are to receive PCI for their STEMI.

Why do you give heparin in a STEMI?

The most important is that the heparin-antithrombin complex cannot bind or inactivate thrombin bound within a clot [1]. Such clot-bound thrombin acts as an important thrombogenic stimulus at a site of coronary thrombosis, particularly after clot disruption by fibrinolytic agents [2].

Which is the best antiplatelet therapy for acute STEMI?

Dual antiplatelet therapy for people with acute STEMI having primary PCI 1.1.11 For people with acute STEMI who are having primary PCI, offer:

How are STEMI patients treated in the hospital?

STEMI Management All patients must be triaged to a monitored resuscitation bay IV access, and blood tests taken Oxygen therapy avoid routine use of oxygen therapy among patients with SaO2 > 93 % use when the SaO2 is below this level… avoid routine use of oxygen therapy among patients with SaO2 >

How long should STEMI be treated with DAPT?

In patients with STEMI treated with DAPT in conjunction with fibrinolytic therapy, P2Y 12 inhibitor therapy (clopidogrel) should be continued for a minimum of 14 days and ideally at least 12 months (Class I). Elective noncardiac surgery should be delayed 30 days after BMS implantation and optimally 6 months after DES implantation.

When to change antiplatelet therapy after myocardial infarction?

Guidelines recommend P2Y 12 inhibitor therapy for 1 year after myocardial infarction ( MI ), yet little guidance is provided on antiplatelet management for patients with recurrent ischemic events during that year. We describe changes in P2Y 12 inhibitor type among patients with recurrent ischemic events in the first year after MI.