Why is ubiquitin ligase SCF important for the cell cycle?

S-phase kinase-associated protein 1 p19 (SKP1)/ Cullin/F-box complex (SCF complex) is one of E3-ubiquitin ligases, which play a very important role in the cell cycle. SCF complex participates in cell cycle regulation by stimulating ubiquitination of the cell cycle proteins and their degradation by the 26S proteasome.

What does SCF stand for in biology?

Abbreviation for stem cell factor.

What is the role of the F-box protein in E3 ligases such as SCF?

The F-box proteins are the substrate recognizing subunits of SCF E3 ligases, thus determining the substrate specificity of SCF E3 ligases (Deshaies and Joazeiro, 2009).

What is APC in cell division?

Anaphase-promoting complex (APC) is a one of ubiquitin ligases, which plays a key role in the cell cycle [1]. APC is mainly required to induce progression and exit from mitosis by inducing proteolysis of different cell cycle regulators.

What does SCF do?

Skp, Cullin, F-box containing complex (or SCF complex) is a multi-protein E3 ubiquitin ligase complex that catalyzes the ubiquitination of proteins destined for 26S proteasomal degradation. Along with the anaphase-promoting complex, SCF has important roles in the ubiquitination of proteins involved in the cell cycle.

What is SCF unit?

In the US and many other countries it is the Standard Cubic Foot (SCF) measured at 60°F and one atmosphere or 14.73 psi (pounds per square inch) of pressure. In Europe and many other countries the standard unit is the Normal Cubic Meter (Nm3) measured at 0°C and one atmosphere of pressure.

What is the full form of SCF?


Acronym Definition
SCF Statistical Collection File
SCF System Communication Function
SCF Standard Change Form
SCF Scheduled Change Factor

How does the proteasome work?

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases. The result is a polyubiquitin chain that is bound by the proteasome, allowing it to degrade the tagged protein.

Which is the variable component of the SCF ligase?

The variable component of the SCF ligase, that determines substrate specificity, is the F-box protein (FBP). FBPs bind Skp1 through an F-box motif initially identified in cyclin F and the substrate bringing the two within close proximity.

What is the role of SCF E3 ubiquitin ligase?

And the SCF E3 ubiquitin ligases play an important role in regulating critical cellular processes, which promote degradation of many cellular proteins, including signal transducers, cell cycle regulators, and transcription factors.

What are the proteins in the SCF complex?

The SCF complexes are E3 ubiquitin ligases that consist of Skp1, Cul1/Cdc53, Roc1, and an F-box-containing protein that confers substrate specificity in a phosphospecific manner [141–144].

What is the role of ring finger in the SCF complex?

Rbx1 contains a Zinc-binding domain called RING Finger that binds to the E2-ubiquitin conjugate, transferred ubiquitin to the lysine residues of the target protein [ 9, 10 ]. As the most crucial component of SCF complex, F-box protein shoulders the responsibility for the recognition of substrates and determines the specificity of the SCF complex.