What does an acetylcholinesterase inhibitor do?

Cholinesterase inhibitors (also called acetylcholinesterase inhibitors) are a group of medicines that block the normal breakdown of acetylcholine. Acetylcholine is the main neurotransmitter found in the body and has functions in both the peripheral nervous system and the central nervous system.

How is acetylcholinesterase inhibitor treated?

Treatments for MG include acetylcholinesterase (AChE) inhibitors (AChEIs), corticosteroids, immunosuppressants, intravenous immunoglobulin, plasma exchange and thymectomy.

What are examples of acetylcholinesterase inhibitors?


  • Physostigmine.
  • Neostigmine.
  • Pyridostigmine.
  • Ambenonium.
  • Demecarium.
  • Rivastigmine.

How do Anticholinesterase inhibitors work?

How do cholinesterase inhibitor drugs work? Cholinesterase inhibitor drugs stop or inhibit enzymes from breaking down acetylcholine when it travels from one cell to another.

What happens if cholinesterase is inhibited?

When AChE is inhibited, acetylcholine can accumulate causing overstimulation of the cholinergic junctions and organs controlled by cholinergic neurons. Tissues innervated by cholinergic neurons include muscles (both smooth and voluntary); glands such as salivary, pancreas, and lachrymal; and certain parts of the brain.

How do acetylcholinesterase inhibitors help with Alzheimer’s?

Donepezil, rivastigmine and galantamine all prevent an enzyme called acetylcholinesterase from breaking down acetylcholine. This means there is a higher concentration of acetylcholine in the brain, which leads to better communication between nerve cells. This may ease some symptoms of Alzheimer’s disease for a while.

How effective is acetylcholinesterase inhibitors?

Between 40 and 70 per cent of people with Alzheimer’s disease benefit from taking a cholinesterase inhibitor. In cases where the treatment shows benefit, symptoms improve temporarily (for between six and 12 months in most cases) and then gradually worsen over the following months.

What are the keywords for acetylcholinesterase reversible inhibitors?

Keywords: Acetylcholine, acetylcholinesterase, Alzheimer’s disease drugs, carbamates, detoxification, irreversible inhibitors, organophosphates, reversible inhibitors. 1.  CHOLINESTERASES

What happens when acetylcholinesterase is inactivated?

The enzyme inactivation, induced by various inhibitors, leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins.

How are AChE inhibitors different from cholinesterase inhibitors?

AChE inhibitors or anti-cholinesterases inhibit the cholinesterase enzyme from breaking down ACh, increasing both the level and duration of the neurotransmitter action. According to the mode of action, AChE inhibitors can be divided into two groups: irreversible and reversible.

How does cholinesterase catalyze the hydrolysis of ACh?

Cholinesterase is a family of enzymes that catalyzes the hydrolysis of the neurotransmitter acetylcholine (ACh) into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It involves two types: