What does ER positive and PR negative mean?
If breast cancer cells have estrogen receptors, the cancer is called ER-positive breast cancer. If breast cancer cells have progesterone receptors, the cancer is called PR-positive breast cancer. If the cells do not have either of these 2 receptors, the cancer is called ER/PR-negative.
Is ER positive good or bad?
About 70 percent of breast cancer patients have positive ER/PR hormone status. While being ER/PR-positive sounds bad, there’s actually a benefit.
What does ER PR Her2 mean?
ER = estrogen receptor, Her2 = human epidermal growth factor receptor 2, PR = progesterone receptor.
Does a high Ki67 score mean that I have a malignant Tumour?
Understanding Your Ki-67 Results A “high” score means that the breast tumor is more likely to be aggressive and spread quickly. Even so, not all doctors order the Ki-67 test, so don’t be alarmed if it’s not on your pathology report.
What is a high Ki67?
A result of less than 6% is considered low, 6-10% intermediate, and more than 10% is considered high. Ki-67: Ki-67 is a protein in cells that increases as they prepare to divide into new cells. A staining process can measure the percentage of tumor cells that are positive for Ki-67.
Can HER2-positive be ER positive?
Triple-positive cancers are ER-positive, PR-positive, and HER2-positive. These cancers can be treated with hormone drugs as well as drugs that target HER2.
Is HER2 metastatic?
About 20% of breast cancers are HER2-positive. They usually grow quicker than other types of cancer. Metastatic HER2-positive breast cancer has spread beyond the breast to other parts of the body.
Is HER2 genetic?
HER2-positive breast cancer is not inherited. Instead, it’s considered a somatic genetic mutation. This type of mutation occurs after conception. Having a close relative with HER2-positive breast cancer does not increase your risk for breast cancer or HER2-positive breast cancer.