Is morphine sulfate same as morphine hydrochloride?

Morphine hydrochloride trihydrate contains almost an equivalent amount of morphine base per milligram as morphine sulphate and morphine tartrate, hence the preparations may be used interchangeably.

What does the sulfate do in morphine?

Morphine sulfate and related opioids depress the cough reflex by direct effect on the cough center in the medulla. Morphine sulfate causes miosis, even in total darkness. Effects on the Gastrointestinal Tract and on Other Smooth Muscle: Gastric, biliary and pancreatic secretions are decreased by morphine sulfate.

Is morphine sulphate acidic?

Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805….Structure for Morphine sulfate (DBSALT000122)

Property Value Source
pKa (Strongest Acidic) 10.26 ChemAxon
pKa (Strongest Basic) 9.12 ChemAxon

What’s the difference between morphine hydrochloride and morphine sulfate?

There was no significant difference in the efficacy between the two medicines. Digestive system adverse events, including nausea, vomiting and constipation, were more common in morphine hydrochloride sustained-released tablet group than in morphine sulfate controlled-released tablet group (66.66% vs. 34.43%, P<0.05).

How to change morphine freebase to HCl salt?

What you now have is pure morphine freebase. Changing to HCl salt is easy, too: 1) Dissolve in anhydrous (99%) alcohol. 2) Add 1ml of HCl and shake. 3) Let the alcohol evaporate (do NOT boil!) and you’ll have some nice morphine hcl crystals. 4) Have fun.

What’s the difference between dirivitive and sulfate drugs?

If there was NO difference they would have the SAME name. The difference could be the inactive ingredients or just the way the drug is chemically formed. One I believe is a pure dirivitive, while the other is a sulfate (salts) form.