Is naringin a Furanocoumarin?
Toxicity. The typical concentration of naringin in grapefruit juice is around 400 mg/l. This would suggest that an inhibitor other than naringin, such as furanocoumarin, which is also found in Seville oranges, may be at work.
Is naringin a flavonoid?
Naringin is a glycoside containing naringenin as aglycone flavonoids, which were found in greater concentration in grapes and citrus fruits. Naringin is a flavanone glycoside that displays strong antiinflammatory and antioxidant activities.
Does lemon contain naringin?
Values for eight flavanones (didymin, eriocitrin, hesperidin, naringin, narirutin, neoeriocitrin, neohesperidin, poncirin) are presented. For lemons, total flavanones (summed means) were 26 mg/100 g and for limes 17 mg/100 g. The flavanone profiles of both lemons and limes were dominated by hesperidin and eriocitrin.
What is naringin good for?
Naringin and its aglycone naringenin belong to this series of flavonoids and were found to display strong anti-inflammatory and antioxidant activities. Several lines of investigation suggest that naringin supplementation is beneficial for the treatment of obesity, diabetes, hypertension, and metabolic syndrome.
What foods contain naringin?
Naringenin and its glycoside has been found in a variety of herbs and fruits, including grapefruit, bergamot, sour orange, tart cherries, tomatoes, cocoa, Greek oregano, water mint, as well as in beans. Ratios of naringenin to naringin vary among sources, as do enantiomeric ratios.
What are the benefits of naringin?
Based on the assessment, naringin could alleviate MetS by reducing visceral obesity, blood glucose, blood pressure, and lipid profile and regulating cytokines. Conclusions. Naringin is an antioxidant that appears to be efficacious in alleviating MetS by preventing oxidative damage and proinflammatory cytokine release.
How is bergamottin related to grapefruit juice?
The interaction of some ingredients of grapefruit juice (bergamottin, 6′,7′-dihydroxybergamottin, 6′,7′-epoxybergamottin, naringin, and naringenin) and the transport of talinolol, a substrate for P glycoprotein, was studied in Caco-2 cells [115 ]. Talinolol permeability was selectively inhibited by grapefruit juice and its components.
How is bergamottin used in the treatment of cancer?
Bergamottin suppressed tumor promotion in mammalian cells through inhibition of superoxide and nitric oxide generation ( Miyake et al 1999 ). Comments: Bergamottin is one of many psoralens found in citrus fruit oils.
What is the IC50 value of bergamottin?
Pharmacokinetics: Bergamottin inhibits CYP3A, with an IC50 value of 22 μM (7.44 mg/L) ( Guo et al 2000) and inhibits CYP3A4 with an IC 50 value of 13.63 μM (4.61 mg/L) ( Modarai et al 2011 ). It is also a potent inhibitor of CYP1A1 and CYP1A2 ( Wen et al 2002; Baumgart et al 2005 ).