What is G-CSF in IVF?

Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine produced in maternofetal interface during embryo implantation and early pregnancy suggesting it may play a role in decidua and placental function (6). It stimulates granulocyte proliferation and differentiation (7).

What is G-CSF injection?

G-CSF (granulocyte-colony stimulating factor) is a type of drug called a growth factor. It increases the number of some types of blood cells in the blood. It can be used with chemotherapy. It can also be used before and after a stem cell transplant. Different types of G-CSF can be used.

How long does G-CSF take to work?

This usually takes 5 to 7 days, although it can be longer. Long-acting G-CSF is given as a single injection the day after chemotherapy has completed. If you are having G-CSF before a stem cell transplant, you usually have your first injection 4 to 6 days before your stem cells are going to be collected.

What does Neupogen do for IVF?

Neupogen is a medication that causes the body to generate neutrophils, a type of white blood cell which plays and important role in the immune system. An individual may benefit from Neupogen if they have experienced multiple miscarriages or failed implantation with IVF.

How can I increase blood flow to my uterus after embryo transfer?

Keep your abdomen warm and use a hot water bottle to help blow flow to the uterus. Acupuncture can also help increase blood flow to the uterus. Most IVF clinics will recommend carrying on as normal once you’ve had the embryo transfer.

Can G-CSF cause leukemia?

A large majority of allogeneic hematopoietic stem cell donations are achieved using granulocyte-colony stimulating factor (G-CSF). G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances.

How do you inject G-CSF?

Hold the syringe in your dominant hand (the hand you use to write). Hold it like you would a pen or a pencil when you’re ready to write. Use your other hand to pinch a fold of skin at the injection site. Insert the needle into your skin in one quick motion at a 90-degree (straight up and down) angle (see Figure 3).

How much endometrial thickness is required for IVF?

Conclusion. Correct transfer depth and endometrial thickness can increase the rates of clinical pregnancy, implantation, and live delivery. Placing the embryos at 10–20 mm from the fundus and at an endometrial thickness of more than 7 mm is recommended for optimal clinical pregnancy outcomes.

What does letrozole do for IVF?

By generating FSH, the ovaries are stimulated to grow more follicles. Letrozole boosts this growth and release of eggs in women who are anovulatory, or not ovulating, and can cause superovulation in women who are already able to ovulate. In both cases, it increases the chances of natural conception.

What is the best sleeping position after IVF?

There’s no evidence to show that any sleeping position is better than any other for embryo implantation. The embryo is transferred when your womb is ready, when the lining is soft and thick and ideal for an embryo to implant. You can lie however you like – just get comfy.

When to use G-CSF in in vitro fertilisation?

It has been used during in vitro fertilisation (IVF) treatment for subfertile women with chronically thin endometrium and those with previous multiple IVF failures. It is currently unknown whether G-CSF is effective in improving results following assisted reproductive technology (ART).

When to use granulocyte colony stimulating factor in IVF?

Granulocyte-colony stimulating factor (G-CSF) seems to play an important role in the process of embryo implantation and continuation of pregnancy. It has been used during in vitro fertilisation (IVF) treatment for subfertile women with chronically thin endometrium and those with previous multiple IVF failures.

Is it safe to use G-CSF in pregnant women?

In subfertile women undergoing ART, we are uncertain whether the administration of G-CSF improves ongoing pregnancy or overall clinical pregnancy rates or reduces miscarriage rate compared to no treatment or placebo, whether in all women or those with thin endometrium, based on very low-quality evidence.