What do you need to know about systemic sclerosis?
Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that is characterised by fibrosis of the skin and internal organs and vasculopathy. Although systemic sclerosis is uncommon, it has a high morbidity and mortality. Improved understanding of systemic sclerosis has al …
Which is a variant of limited cutaneous systemic sclerosis?
CREST (calcinosis cutis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia) syndrome is a variant of limited cutaneous systemic sclerosis.
What kind of rheumatic disease is systemic sclerosis?
DOI: 10.1016/S0140-6736(17)30933-9 Abstract Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that is characterised by fibrosis of the skin and internal organs and vasculopathy.
How is cyclophosphamide used to treat systemic sclerosis?
Treating active interstitial lung disease with oral cyclophosphamide (Cytoxan) for one year modestly improves lung function, dyspnea, skin thickening, and health-related quality of life in patients with systemic sclerosis.
Definition. Systemic sclerosis (SSc), also known as scleroderma, is a multi-system, autoimmune disease, characterised by functional and structural abnormalities of small blood vessels, fibrosis of skin and internal organs, and production of auto-antibodies.
How is systemic sclerosis a connective tissue disease?
Electronic address: [email protected] Systemic sclerosis is an autoimmune connective tissue disease, which is characterised by immune dysregulation and progressive fibrosis that typically affects the skin, with variable internal organ involvement.
How to treat systemic sclerosis-associated interstitial lung disease?
Systemic sclerosis-associated interstitial lung disease most commonly presents with dyspnoea, cough, and a non-specific interstitial pneumonia pattern on CT scan, with a minority of cases fulfilling the criteria for usual interstitial pneumonia. The standard therapy has traditionally been combinations of immunosuppressants,
Can you have systemic sclerosis without skin thickening?
In diffuse cutaneous SSc, the skin thickening can additionally involve the upper arms, thighs, and the trunk. It is possible to have Systemic Sclerosis without skin thickening (sine scleroderma), which is when a patient has the internal organ manifestations without the skin findings, but this is very rare.
How is the severity score determined on Qualys?
Qualys assigns every vulnerability in the Knowledge Base a severity score that is determined by the security risk associated with its exploitation. In addition, to this broad guidance the service also takes into consideration factors like complexity of the exploit and likelihood of the exploit to work under normal conditions.
How big is the sensor on the oqus qualisys?
For example, the Oqus 3+ is able to capture at 1 750 fps, with full FOV and a sensor resolution of 640 × 512. More impressive is the Oqus 7+. which is able to capture at 1 100 fps with full FOV and a resolution of 3 megapixels.
Is there a temporal score for Qualys signature engineers?
Such scores are footnoted in the Qualys Knowledgebase. If there is no Temporal Score, Qualys signature engineers enter the temporal score based on best judgment of the engineer. Qualys managers may add CVSS Environmental Metrics to Asset Groups if the use of full CVSS scoring methodology is desired.