What is rHuPH20?

Recombinant human PH20 hyaluronidase (rHuPH20) is used to facilitate dispersion of subcutaneously delivered fluids and drugs.

What does Halozyme do?

Halozyme is a biotechnology company focused on novel biological and drug delivery approaches. Our goal is to bring innovative and disruptive solutions that improve the patient experience and, potentially patient outcomes, when our technology is combined with established or emerging treatments.

When was halozyme founded?


San Diego, California, U.S. Halozyme Therapeutics is an American biotechnology company that develops novel oncology therapies designed to target the tumor microenvironment and licenses a novel drug delivery technology through corporate partnerships. The company was founded in 1998 and went public in 2004.

Who owns Halozyme?

Top 10 Owners of Halozyme Therapeutics Inc

Stockholder Stake Shares owned
The Vanguard Group, Inc. 9.30% 13,238,969
Artisan Partners LP 7.16% 10,189,688
SSgA Funds Management, Inc. 3.63% 5,161,793
William Blair Investment Manageme… 3.44% 4,901,938

How do you inject hylenex?

Lightly pinch the skin up into a small mound and insert the needle/catheter into the subcutaneous space. Inject HYLENEX recombinant through the catheter hub or injection port closest to the needle/catheter. Begin administration of solution. Solution should start in readily.

What is hyaluronidase enzyme?

Abstract. Hyaluronidase, an enzyme that breaks down hyaluronic acid, has long been used to increase the absorption of drugs into tissue and to reduce tissue damage in cases of extravasation of a drug.

Does hyaluronidase work immediately?

Hyaluronidase works very quickly, with most of the effect taking place within 24 hours. You should be able to see defined improvement and less filler in the area injected, beginning within a few hours.

Does hylenex expire?

Answer: Nothing that is expired should be used by an injector and that physician should have long discarded that product!

Does hyaluronidase ruin your skin?

For Extravasation: “Hyaluronidase permanently destroyed my skin. It did not detect the dermal filler in my face, causing my skin’s own tissue to dissolve. I am now left with caved in cheeks, deep dents under my eyes along with loose, saggy and stretchy skin.

How much hyaluronidase does it take to dissolve filler?

How much hyaluronidase should you use? Some use 150 units per mL; A simple rule of thumb for each 10th of a cc of Restylane, use about 5 units of Vitrase; (remember that the units across every brand may not be the same); 10 units if you’re trying to dissolve Juvederm; and probably about 15 units for Voluma.

Why was Halozyme awarded an US patent for rHuPH20?

“These foundational patents, and the protection provided, are of significant value to Halozyme and to its development partners, and cover major pharmaceutical markets of the world.” The claims for the newly issued U.S. patent cover compositions of matter and pharmaceutical compositions for rHuPH20 including:

What kind of drug is Halozyme working on?

Company history. Halozyme’s business is primarily focused on its proprietary and patented recombinant human hyaluronidase enzyme, rHuPH20. The company’s development pipeline is concentrated in clinical stage and pre-clinical stage oncology products, including its proprietary investigational drug, PEGPH20, a pegylated version of rHuPH20,…

Why did Halozyme stop development of PEGPH20?

The goal of PEGPH20 is to break down HA so that some anti-cancer therapies and activated immune cells can better reach the cancer cells of HA-high tumors. On November 4, 2019, Halozyme announced it has halted development of PEGPH20.

How is the immunogenicity of rHuPH20 measured?

This report summarizes rHuPH20 immunogenicity findings from clinical trials where rHuPH20 was co-administered with SC human immunoglobulin, trastuzumab, rituximab, or insulin. Plasma samples were obtained from evaluable subjects participating in ten different clinical trials as well as from healthy plasma donors.