What is the function of GLUT1?

The glucose transporter GLUT1, a plasma membrane protein that mediates glucose homeostasis in mammalian cells, is responsible for constitutive uptake of glucose into many tissues and organs. Many studies have focused on its vital physiological functions and close relationship with diseases.

What is the difference between GLUT1 and Glut4?

While both Glut1 and Glut4 transport glucose with high affinity, their properties of transport differ. Glucose transport under equilibrium exchange conditions show a K(m) for Glut4 which is 3- to 12-fold lower than that of Glut138-40 but under zero-trans conditions, Glut4 has a higher K(m) than Glut1.

Where are GLUT1 receptors found?

GLUT1 is highly abundant in the mammalian erythrocyte membrane where it can rapidly equilibrate glucose between the cytoplasm of the erythrocyte and the blood plasma. GLUT1 is also found in brain tissues. GLUT1 can also transport mannose, galactose, and glucosamine.

What is the difference between GLUT2 4 5?

GLUT2 is insulin independent (Liver and pancreas), GLUT4 is insulin dependent (on muscle, adipose, heart). GLUT2 has a higher Km and so transport is not maximally active at low concentrations. Postprandially when blood glucose is higher than the km transport into liver and pancreas will be high.

How rare is GLUT1?

GLUT1 deficiency syndrome is a rare disorder. Approximately 500 cases have been reported worldwide since the disorder was first identified in 1991. In Australia, the prevalence of the disorder has been estimated at 1 in 90,000 people.

Is GLUT1 found in all cells?

GLUT1 (SLC2A1) is a high-affinity glucose transporter found in almost every tissue with varying expression levels in different cell types.

Is GLUT1 hereditary?

This condition is usually inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. About 90 percent of cases of GLUT1 deficiency syndrome result from new mutations in the gene.

Is glut a Uniporter?

Glucose transport facilitators (GLUT proteins) are uniporters which catalyze the diffusion of glucose into (or out of) cells along the concentration gradient [1, 2].

¿Qué es el GLUT1 y dónde se encuentra?

¿Qué es el GLUT1 y dónde se encuentra? El cerebro: en la barrera hematoencefálica (se trata de una barrera natural que protege al cerebro de la llegada de toxinas o gérmenes que puedan encontrarse en la sangre). Los glóbulos rojos.

¿Cuáles son los GLUT que se han descrito?

Esta revisión se centrará en los 14 GLUT que hasta el momento se han descrito. A pesar de la homología estructural de los GLUT, las alteraciones genéticas en estos provocan diferentes entidades clínicas específicas.

¿Cuáles son los síntomas para el síndrome de deficiencia en GLUT1?

Los cri- terios diagnósticos para el síndrome de deficiencia en GLUT1 son los siguientes: convulsiones, retraso en el desarrollo, desorden complejo del movimiento y cam- bios electroencefalográficos en el ayuno15.

¿Cuáles son las propiedades de los Glut?

Los GLUT se expresan en todas las células del organismo y permiten mo- ver la glucosa de un compartimiento a otro. Un resumen de las propiedades de los miembros de estas dos familias se encuentran en la Tabla 1.